I often use coin control together with PrivateSend so that I can send the whole amount (and avoid paying up to 0.01 fee) by copying the value in "After Fee" field. If you do that then technically there is no difference whether you have PrivateSend enabled or not because you are not receiving any change anyway. However, as strophy suggested, it is better to have PrivateSend enabled to ensure that you don't accidentally receive any change or use unmixed inputs.