I have a lot of "Handshake timed out" events from my other p2pool nodes (they have no miners connected, I run them for experimentation), on other VMs:
2014-05-24 00:02:14.597051 Handshake timed out, disconnecting from 10.0.2.2:48893
2014-05-24 00:04:54.774054 Handshake timed out, disconnecting...